BDBM21015 (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide::2-Ala-4-MePhe-5-Gly-Enkephalin::CHEMBL38874::D-Ala2-MePhe4-Met(0)5-enkephalin-ol::DAMGO::RX 783006::US11492374, ID 2::[3H]DAMGO::[tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin
SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
InChI Key InChIKey=HPZJMUBDEAMBFI-WTNAPCKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 37 hits for monomerid = 21015
Affinity DataKi: 0.660nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in HN9.10 cellsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 127nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 180nMAssay Description:Binding affinity against Opioid receptor delta 1 in P2 membrane preparation of rat brain by [3H]DADLE displacement.More data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Binding affinity for delta opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Displacement of [3H]C1-DPDPE from human recombinant Opioid receptor delta 1 on CHO cell membranes.More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 469nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 567nMAssay Description:Binding affinity against Opioid receptor delta 1More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 629nMAssay Description:Binding affinity of the compound to opioid receptor delta was determined in rat brain using [3H]-DSTBULET as radioligandMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 700nMAssay Description:Ability to inhibit the binding of [3H]DSLET to Opioid receptor delta 1 in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 980nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
Affinity DataKi: 990nMAssay Description:Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 1.28E+3nMAssay Description:Binding affinity against Opioid receptor delta 1 by displacement of radioligand [3H]-DSLET in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting a...More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Displacement of [3H]-DADLE from human delta opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Displacement of [3H]DADLE from human recombinant opioid delta receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting m...More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Displacement of [3H]DADLE from human delta opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 2.67E+3nMAssay Description:Displacement of [3H]DPDPE from Sprague-Dawley rat delta opioid receptor by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Ile5,6deltorphin-2 from delta opioid receptor in Wistar rat brain membranes by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:In vitro potency was measured against human Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+3nMAssay Description:Displacement of [125I]-Deltorphin 2 from mouse Flag-tagged delta-opioid receptor expressed in HEK293 cell membranes after 60 mins by gamma countingMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Agonist activity at delta-opioid receptor in mouse vasa deferens assessed as inhibition of electrically induced contractionsMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataEC50: 49nMAssay Description:Tested for thromboxane antagonist potency (pA2) against U 44619 induced platelet aggregation using human platelet rich plasmaMore data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Agonist activity at human DOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.85E+3nMAssay Description:Binding affinity against Delta opioid receptor in using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 20 nM NTIMore data for this Ligand-Target Pair
Affinity DataKd: 1.85E+3nMAssay Description:Binding affinity against Delta opioid receptor in using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 20 nM NTIMore data for this Ligand-Target Pair
Affinity DataEC50: 6.90nMAssay Description:Partial agonist activity at human DOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding at human recombinant Opioid receptor delta 1 transfected into CHO cells.More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: 727nMAssay Description:Displacement of [3H]deltorphin2 from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair